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Runx3 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
OSR00334W-100UL
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ Ig
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide from aa region 160-210 of human RUNX3 conjugated to an immunogenic carrier protein was used as the antigen
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
Conc. Not Determined
保存液
whole serum
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in rat and mouse.
Specificity of this antibody: Runx3.
靶标信息
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Acute myeloid leukemia 2 protein; CBF-alpha 3; CBF-alpha-3; Core-binding factor subunit alpha-3; Oncogene AML-2; PEA2-alpha C; Polyomavirus enhancer-binding protein 2 alpha C subunit; Runt related transcription factor 3; Runt-related transcription factor 3; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit
基因别名: AML2; CBFA3; PEBP2A3; RUNX3
Entrez Gene ID: (Rat) 156726
negative regulation of transcription from RNA polymerase II promoter
chondrocyte differentiation
regulation of transcription, DNA-templated
protein phosphorylation
axon guidance
biological_process
hair follicle morphogenesis
neuron projection development
interferon-gamma production
mRNA transcription from RNA polymerase II promoter
negative regulation of cell cycle
cell maturation
negative regulation of epithelial cell proliferation
positive regulation of extrinsic apoptotic signaling pathway
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
