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LRFN1 is one of a family of five transmembrane glycoproteins that are highly expressed in neuronal tissues. LRFN proteins share leucine-rich repeat (LRR)-immunoglobulin-like (Ig)-fibronectin type III (Fn)-transmembrane domain structure with other members of the LRR-Ig-Fn protein superfamily such as the Slitrk family of proteins. Expression of LRFN1, -3, and -4 mRNA was detected in embryonic neuronal cells, while Lrfn2 and Lrfn5 expression was primarily restricted to more mature cells. LRFN1, -2, and -4 bound to PDZ domains of postsynaptic PSD95, re-distributing PSD95 to the cell periphery. It has been suggested that the Lrfn proteins play a role in the developing and/or mature vertebrate nervous system. At least two isoforms of LRFN1 are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CTC-246B18.8; Leucine-rich repeat and fibronectin type III domain-containing protein 1; Synaptic adhesion-like molecule 2; synaptic differentiation enhancing molecule 1; Synaptic differentiation-enhancing molecule 1
基因别名: BC004018; KIAA1484; LRFN1; SALM2; Semo1
UniProt ID: (Human) Q9P244, (Mouse) Q2WF71, (Rat) P0C7J6
Entrez Gene ID: (Human) 57622, (Mouse) 80749, (Rat) 365222