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Invitrogen
SAP18 Polyclonal Antibody
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SAP18 Antibody (PA5-92207) in IHC (P)
Immunohistochemistry analysis of SAP18 in paraffin-embedded mouse brain. Samples were incubated with SAP18 Polyclonal antibody (Product # PA5-92207) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-92207
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 21-172 of human SAP18 (NP_0058612)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.91 mg/mL
规格
91 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: AVESRVTQEE IKKEPEKPID REKTCPLLLR VFTTNNGRHH RMDEFSRGNV PSSELQIYTW MDATLKELTS LVKEVYPEAR KKGTHFNFAI VFTDVKRPGY RVKEIGSTMS GRKGTDDSMT LQSQKFQIGD YLDIAITPPN RAPPPSGRMR PY; Positive Samples: SW480; Cellular Location: Cytoplasm, Nucleus, Nucleus speckle
靶标信息
SAP18 is involved in histone acetylation, which plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 18 kDa Sin3-associated polypeptide; Histone deacetylase complex subunit SAP18; Sin3-associated polypeptide p18; sin3-associated polypeptide, 18kDa; Sin3A-associated protein, 18kDa
基因别名: C530046K05Rik; D11Ertd539e; EMegR4; Sap18; Sinbp1
UniProt ID: (Mouse) O55128
Entrez Gene ID: (Mouse) 20220, (Rat) 290284
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