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Fabgennix
SAPOSIN-C Polyclonal Antibody, Biotin
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产品信息
SAPC-BIOTIN
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide taken within amino acid region 460-510 on mouse Saposin-C.
偶联物
Biotin
Biotin
Biotin
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Saposin C is one of four homologous proteins derived from sequential cleavage of the saposin precursor protein, prosaposin. It is an essential activator for glucocerebrosidase, the enzyme deficient in Gaucher disease. Gaucher disease is a rare autosomal recessive lysosomal storage disorder caused by mutations in the GBA gene that exhibits vast phenotypic heterogeneity, despite its designation as a simple Mendelian disorder. The observed phenotypic variability has led to a search for disease modifiers that can alter the Gaucher phenotype. The PSAP gene encoding saposin C is a prime candidate modifier for Gaucher disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: prosaposin (sulfated glycoprotein, sphingolipid hydrolase activator); Psap; snoRNA MBII-198; sphingolipid activator protein; sulfated glycoprotein 1; sulfated glycoprotein precursor; Uncharacterized protein; unnamed protein product
基因别名: SGP-1; SGP1A
UniProt ID: (Mouse) Q61207, (Rat) P10960
Entrez Gene ID: (Mouse) 19156, (Rat) 25524
G-protein coupled receptor binding
protease binding
protein binding
phospholipid binding
lipid binding
sphingolipid activator protein activity
lipid antigen binding
identical protein binding
protein homodimerization activity
scaffold protein binding
ganglioside GM1 binding
ganglioside GM2 binding
ganglioside GM3 binding
ganglioside GT1b binding
ganglioside GP1c binding
lipid chaperone activity
NK T cell differentiation
corneocyte development
lipid metabolic process
glycolipid metabolic process
sphingolipid metabolic process
ceramide metabolic process
glucosylceramide metabolic process
galactosylceramide catabolic process
sphingomyelin catabolic process
intracellular protein transport
lysosomal transport
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
sensory perception of sound
protein secretion
gene expression
regulation of lipid metabolic process
antigen processing and presentation
cerebellar Purkinje cell differentiation
sphingolipid catabolic process
cellular response to reactive oxygen species
myelination
regulation of MAPK cascade
positive regulation of MAPK cascade
developmental growth
neurological system process
neuromuscular process controlling balance
positive regulation of hydrolase activity
micturition
prostate gland growth
epithelial cell differentiation involved in prostate gland development
inclusion body assembly
cochlea development
walking behavior
cornified envelope assembly
lysosomal protein catabolic process
ganglioside GM1 transport to membrane
glycolipid transport
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