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Invitrogen
SELK Polyclonal Antibody
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Product Details
PA5-34420
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
An 18 amino acid synthetic peptide near the carboxy terminus of human SELK
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is A-20 cell lysate.
PA5-34420 can be used with blocking peptide PEP-1462.
Target Information
SELK is a selenoprotein, containing a selenocysteine residue at its active site. SELK is localized to the endoplasmic reticulum and is highly expressed in the heart, where it may function as an antioxidant. SELK can bind to proteins such as the ER-associated degradation (ERAD) components p97 ATPase, Derlin-1 and -2, and SelS as well as proteins in the oligosaccharyltransferase complex, suggesting that SELK may be involved in the Derlin-dependent ERAD of glycosylated misfolded proteins. SELK is also thought to be important in Ca2+ flux in immune cells, and is cleaved by m-calpain in resting macrophages. When these macrophages are activated through different Toll-like receptors, this cleavage is inhibited.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: heat shock protein; heat shock protein, 30 kDa; Selenoprotein K; SelK
Gene Aliases: 1110001C03Rik; AA673253; Hsp30; HSPC030; HSPC297; SELENOK; SELK
UniProt ID: (Human) Q9Y6D0, (Mouse) Q9JLJ1, (Rat) P59798
Entrez Gene ID: (Human) 58515, (Mouse) 80795, (Rat) 290549
calcium ion transport
response to oxidative stress
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
transport
ion transport
macrophage derived foam cell differentiation
protein palmitoylation
positive regulation of cell migration
positive regulation of T cell proliferation
respiratory burst after phagocytosis
regulation of protein transport
positive regulation of T cell migration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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