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Invitrogen
SEMA6B Polyclonal Antibody
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FIGURE: 1 / 1
SEMA6B Antibody (PA5-47251) in IHC (P)
Immunohistochemical analysis of SEMA6B in immersion fixed paraffin-embedded sections of Human Brain Cortex. Samples were incubated with SEMA6B Polyclonal Antibody (Product # PA5-47251) using a dilution of 15 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG HRP Secondary Antibody. Tissue was stained with DAB (brown) and counterstained with hematoxylin (blue).
Product Details
PA5-47251
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Semaphorin 6B Leu26-Ser603
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs, approximately 15% cross-reactivity with recombinant human (rh) Semaphorin 6C is observed, 5% cross-reactivity with rhSemaphorin 6D is observed and less than 1% cross-reactivity with rhSemaphorin 3A, rhSemaphorin 3B, rhSemaphorin 6A, rhSemaphorin 7A, recombinant mouse (rm) Semaphorin 3C, rmSemaphorin 3E, and rmSemaphorin 3F is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
The SEMA6B gene encodes semaphorin 6B, which belongs to the semaphorin family of proteins known for their roles in guiding axonal development and modulating cellular signaling pathways. Semaphorin 6B primarily functions in the nervous system where it influences axonal guidance, neuronal development, and synapse formation through interactions with neuropilin and plexin receptor complexes. These interactions are crucial during neural development, ensuring proper neuronal wiring and the establishment of functional neural circuits. In addition to its key role in neural connectivity, SEMA6B is increasingly recognized for its involvement in immune responses, where it can modulate the activity and migration of immune cells. In cancer biology, altered expression of SEMA6B has been implicated in tumor progression, affecting tumor cell adhesion and migration, thereby influencing metastasis. Research continues to explore the specific mechanisms of SEMA6B's action and how it can be targeted for therapeutic interventions in neural and cancer-related diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B; Sema N; Sema VIB; Sema Z; Semaphorin VIB; semaphorin Z; Semaphorin-6B; semaphorin-6Ba; Semaphorin-N; Semaphorin-Z
Gene Aliases: SEM-SEMA-Y; Sema; SEMA-VIB; SEMA6B; SEMAN; SEMAZ; UNQ1907/PRO4353; VIb
UniProt ID: (Human) Q9H3T3, (Mouse) O54951
Entrez Gene ID: (Human) 10501, (Mouse) 20359
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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