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Invitrogen
SERTAD1 Polyclonal Antibody
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SERTAD1 Antibody (PA5-97134) in WB
Western blot analysis of SERTAD1 in extracts of various cell lines. Samples were incubated with SERTAD1 Polyclonal antibody (Product # PA5-97134) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 30s.
产品信息
PA5-97134
产品规格
种属反应
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-236 of human SERTAD1 (NP_0375082)
偶联物
形式
Liquid
浓度
2.75 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MLSKGLKRKR EEEEEKEPLA VDSWWLDPGH TAVAQAPPAV ASSSLFDLSV LKLHHSLQQS EPDLRHLVLV VNTLRRIQAS MAPAAALPPV PSPPAAPSVA DNLLASSDAA LSASMASLLE DLSHIEGLSQ APQPLADEGP PGRSIGGAAP SLGALDLLGP ATGCLLDDGL EGLFEDIDTS MYDNELWAPA SEGLKPGPED GPGKEEAPEL DEAELDYLMD VLVGTQALER PPGPGR; Positive Samples: Rat testis, Rat lung
靶标信息
SEI-1, also known as SERTAD1 (SERTA domain containing 1) or TRIP-Br1 (Transcriptional regulator interacting with the PHD-bromodomain 1), is a transcriptional regulator that integrates signals provided by transcription factors. Acting at E2F-responsive promoters, SEI-1 interacts with the PHD- and bromodomains of proteins such as TIF1 and DP-1, thereby transmitting their signals to the promoter and stimulating transcriptional activity. SEI-1 exists as a multiprotein complex with E2F-1 and DP-1 and is expressed at different levels throughout the cell cycle, allowing it to regulate cell cycle progression via promoter control during the G1 and S phases. Additionally, SEI-1 can render the activity of the cyclin D-Cdk4 complex, an important catalyst of the cell cycle, resistant to the inhibitory effects of p16. Overexpression of SEI-1 is implicated in the development of squamous cell carcinomas of the head and neck.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: SERTA domain-containing protein 1
Entrez Gene ID: (Rat) 361526
