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Invitrogen
SETD1B Polyclonal Antibody
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SETD1B Antibody (PA5-40072) in WB
Western Blot was performed on whole cell lysates from mouse fibroblasts (NIH3T3) and embryonic stem cells (E14Tg2a) using a SETD1B polyclonal antibody (Product # PA5-40072) at a dilution of 1:500 in BSA/PBS-Tween. The molecular weight marker (kDa) is shown on the left; the location of the protein of interest is indicated on the right.
产品信息
PA5-40072
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH-conjugated synthetic peptides containing sequences from the central part of the protein corresponding to mouse Setd1b (Set domain containing 1B).
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
whole serum
内含物
0.05% sodium azide
保存条件
-20°C or -80°C if preferred
RRID
靶标信息
Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. VISA is a mitochondrial membrane protein that was identified as a critical component in the IFN-b signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappa-B. VISA is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. VISA also interacts with the IKK-a, IKK-b and IKK-iota kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. At least three isoforms of VISA are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Histone-lysine N-methyltransferase SETD1B; SET domain-containing protein 1B
基因别名: AA516740; BC035291; Kiaa1076; KMT2G; mKIAA1076; Set1b; Setd1b
UniProt ID: (Mouse) Q8CFT2
Entrez Gene ID: (Mouse) 208043
