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Invitrogen
SETDB1 Polyclonal Antibody
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SETDB1 Antibody (PA5-96517) in WB
Western blot analysis of SETDB1 in extracts of various cell lines. Samples were incubated with SETDB1 Polyclonal antibody (Product # PA5-96517) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3s.
产品信息
PA5-96517
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-397 of human SETDB1 (NP_0012304201)
偶联物
形式
Liquid
浓度
2.56 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MSSLPGCIGL DAATATVESE EIAELQQAVV EELGISMEEL RHFIDEELEK MDCVQQRKKQ LAELETWVIQ KESEVAHVDQ LFDDASRAVT NCESLVKDFY SKLGLQYRDS SSEDESSRPT EIIEIPDEDD DVLSIDSGDA GSRTPKDQKL REAMAALRKS AQDVQKFMDA VNKKSSSQDL HKGTLSQMSG ELSKDGDLIV SMRILGKKRT KTWHKGTLIA IQTVGPGKKY KVKFDNKGKS LLSGNHIAYD YHPPADKLYV GSRVVAKYKD GNQVWLYAGI VAETPNVKNK LRFLIFFDDG YASYVTQSEL YPICRPLKKT WEDIEDISCR DFIEEYVTAY PNRPMVLLKS GQLIKTEWEG TWWKSRVEEV DGSLVRILFL VLFFSTILEA EVGGGGT; Positive Samples: HeLa, MCF7, DU145, HL-60, Jurkat, 293T, Mouse thymus; Cellular Location: Chromosome, Nucleus
靶标信息
This gene encodes a histone methyltransferase. The encoded enzyme catalyzes the reaction of S-adenosyl-L-methionine and histone L-lysine to produce S-adenosyl-L-homocysteine and histone N(6)-methyl-L-lysine. The encoded protein likely functions in transcriptional repression. Alternatively spliced transcript variants have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ERG-associated protein with a SET domain, ESET; ERG-associated protein with SET domain; ESET; H3-K9-HMTase 4; Histone H3-K9 methyltransferase 4; Histone-lysine N-methyltransferase SETDB1; histone-lysine N-methyltransferase, H3lysine-9 specific 4; Lysine N-methyltransferase 1E; SET domain bifurcated 1; SET domain ERG-associated histone methyltransferase; SET domain, bifurcated 1; tudor domain containing 21
基因别名: AU022152; ESET; H3-K9-HMTase4; KG1T; KIAA0067; KMT1E; mKIAA0067; SETDB1; TDRD21
UniProt ID: (Human) Q15047
Entrez Gene ID: (Human) 9869, (Mouse) 84505, (Rat) 689883
transcription, DNA-templated
Ras protein signal transduction
response to vitamin
histone lysine methylation
response to ethanol
positive regulation of methylation-dependent chromatin silencing
negative regulation of transcription from RNA polymerase II promoter
inner cell mass cell proliferation
regulation of transcription, DNA-templated
chromatin modification
methylation
histone H3-K9 trimethylation
bone development
