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Bethyl Laboratories
SHARP Polyclonal Antibody
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SHARP Antibody (A301-119A) in IP
Detection of human SHARP by western blot of immunoprecipitates. Samples: Whole cell lysate (1.0 mg per IP reaction; 5% of IP loaded) from HEK293T cells prepared using NETN lysis buffer. Antibodies: Affinity purified rabbit anti-SHARP antibody (Product # A301-119A) (lot 3) used for IP at 6 µg per reaction. SHARP was also immunoprecipitated by a second antibody against a different epitope of SHARP (A301-120A). For blotting immunoprecipitated SHARP, A301-119A was used at 0.1 µg/mL. Detection: Chemiluminescence with an exposure time of 10 seco... View More
产品信息
A301-119A
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 1350 and 1400 of Human SMART/HDAC1 associated repressor protein (spen homolog, transcriptional regulator).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
tris citrate/phosphate, pH 7-8
内含物
0.09% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Mouse
靶标信息
May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Msx2 interacting nuclear target (MINT) homolog; Msx2-interacting protein; nuclear receptor transcription cofactor; SMART/HDAC1-associated repressor protein; SPEN homolog; spen homolog, transcriptional regulator
基因别名: HIAA0929; KIAA0929; MINT; RBM15C; SHARP; SPEN
UniProt ID: (Human) Q96T58
Entrez Gene ID: (Human) 23013
