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Invitrogen
SHISA7 Polyclonal Antibody
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产品信息
PA5-63631
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.05 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: VGAKVAFSKA SRAPRAHRDI NVPRALVDIL RHQA
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.
靶标信息
The SHISA7 gene encodes a member of the Shisa family proteins, which are involved in the regulation of signaling pathways critical for embryonic development and cellular communication. SHISA7 is particularly influential in modulating synaptic transmission in the central nervous system. It plays a key role in regulating the surface expression and activity of AMPA-type glutamate receptors, which are crucial for fast excitatory neurotransmission and synaptic plasticity in the brain. By controlling the trafficking and localization of these receptors, SHISA7 impacts synaptic strength and neuronal excitability, affecting learning, memory, and other cognitive functions. The functional regulation by SHISA7 of AMPA receptors can have implications for neuropsychiatric disorders, where dysregulation of synaptic transmission is a common feature. Understanding SHISA7's role in synaptic modulation could lead to insights into the mechanisms underlying cognitive processes and the development of therapeutic strategies for neurological conditions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CKAMP59; Cystine-knot AMPAR modulating protein of 59 kDa; GABA(A) receptor auxiliary subunit Shisa7; hCG_2039146; Protein shisa-6-like; Protein shisa-7; shisa homolog 7; UPF0626 protein A
基因别名: SHISA7
UniProt ID: (Human) A6NL88
Entrez Gene ID: (Human) 729956
