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Invitrogen
SHMT1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-54758
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.1 mg/mL
规格
10 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MTMPVNGAHK DADLWSSHDK MLAQPLKDSD VEVYNIIKKE SNRQRVGLEL IASENFASRA VLEALGSCL
Highest antigen sequence identity to the following orthologs: Mouse - 78%, Rat - 75%.
靶标信息
This gene encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in 2 transcript variants encoding 2 different isoforms. Additional transcript variants have been described, but their biological validity has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cytoplasmic serine hydroxymethyltransferase; F20D10.50; F20D10_50; glycine hydroxymethyltransferase; L-allo-threonine/L-threonine aldolase SHMT1; MGC15229; MGC24556; SERINE HYDROXYMETHYLTRANSFERASE 1; serine hydroxymethyltransferase 1 (soluble); serine methylase; SERINE TRANSHYDROXYMETHYLASE; SERINE TRANSHYDROXYMETHYLTRANSFERASE; serine transhydroxymethyltransferase 1; SHM1; STM; unnamed protein product
基因别名: CSHMT; hcSHMT; SHMT
UniProt ID: (Human) P34896
Entrez Gene ID: (Human) 6470
translation repressor activity, nucleic acid binding
glycine hydroxymethyltransferase activity
threonine aldolase activity
protein binding
lamin binding
L-allo-threonine aldolase activity
aldehyde-lyase activity
pyridoxal phosphate binding
small molecule binding
identical protein binding
protein homodimerization activity
mRNA 5'-UTR binding
phenylserine aldolase activity
serine binding
hydroxytrimethyllysine aldolase activity
'de novo' pyrimidine nucleobase biosynthetic process
dTMP biosynthetic process
DNA replication
glycine metabolic process
glycine biosynthetic process
L-serine metabolic process
L-serine catabolic process
one-carbon metabolic process
purine nucleobase biosynthetic process
negative regulation of translation
tetrahydrofolate interconversion
carnitine biosynthetic process
tetrahydrofolate metabolic process
folic acid metabolic process
protein homotetramerization
cellular response to tetrahydrofolate
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