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Proteintech
SHMT2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
11099-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
SHMT2 Fusion Protein Ag1584 (205-504 aa encoded by BC011911)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.2 mg/mL
规格
30 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: DYNQLALTA RLFRPRLIIA GTSAYARLID YARMREVCDE VKAHLLADMA HISGLVAAKV IPSPFKHADI VTTTTHKTLR GARSGLIFYR KGVKAVDPKT GREIPYTFED RINFAVFPSL QGGPHNHAIA AVAVALKQAC TPMFREYSLQ VLKNARAMAD ALLERGYSLV SGGTDNHLVL VDLRPKGLDG ARAERVLELV SITANKNTCP GDRSAITPGG LRLGAPALTS RQFREDDFRR VVDFIDEGVN IGLEVKSKTA KLQDFKSFLL KDSETSQRLA NLRQRVEQFA RAFPMPGFDE H (205-504 aa encoded by BC011911)
靶标信息
Mammalian serine hydroxymethyltransferase (SHMT) is a tetrameric, pyridoxal phosphate (PLP)-dependent enzyme that catalyzes the reversible interconversion of serine and tetrahydrofolate to glycine and methylenetetrahydrofolate in the cytoplasm (cSHMT, SHMT1) and mitochondria (mSHMT, SHMT2). cSHMT preferentially supplies one-carbon units for thymidylate biosynthesis, depletes methylenetetrahydrofolate pools for S-adenosylmethionine (SAM) synthesis by synthesizing serine, sequesters 5-methyltetrahydrofolate, and inhibits SAM synthesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: epididymis secretory sperm binding protein Li 51e; GLY A+; glycine auxotroph A, human complement for hamster; glycine hydroxymethyltransferase; mitochondrial serine hydroxymethyltransferase; serine aldolase; serine hydroxymethylase; serine hydroxymethyltransferase 2 (mitochondrial); serine hydroxymethyltransferase 2 (mitochondrial) isoform SHMT2_1; serine hydroxymethyltransferase 2 (mitochondrial) isoform SHMT2_2; serine methylase; SHMT 2; threonine aldolase; unnamed protein product
基因别名: 2700043D08Rik; GLYA; HEL-S-51e; mSHMT; NEDCASB; SHMT
UniProt ID: (Human) P34897, (Mouse) Q9CZN7
Entrez Gene ID: (Human) 6472, (Mouse) 108037, (Rat) 299857
regulation of oxidative phosphorylation
glycine metabolic process
glycine biosynthetic process
L-serine metabolic process
L-serine biosynthetic process
L-serine catabolic process
one-carbon metabolic process
positive regulation of cell proliferation
formate biosynthetic process
response to type I interferon
tetrahydrofolate interconversion
tetrahydrofolate metabolic process
protein tetramerization
protein homotetramerization
regulation of mitochondrial translation
protein K63-linked deubiquitination
regulation of aerobic respiration
response to vitamin B6
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