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SHP2 Antibody (710867) in WB
Western blot analysis was performed on whole cell extracts (30 µg lysate) of HeLa (Lane 1), Jurkat (Lane 2), K562 (Lane 3), U-87 MG (Lane 4), MCF7 (Lane 5), PC-3 (Lane 6). The blots were probed with Anti-SHP2 Recombinant Rabbit Superclonal™ Antibody (Product # 710867, 1-2 µg/mL) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.4 µg/mL, 1:2500 dilution). A 65 kDa band corresponding to SHP2 was observed. Known quantity of protein samples were electr... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
710867
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Superclonal
类型
Antibody
克隆号
16HCLC
抗原
Protein corresponding to Human PTPN11 (aa 2-597)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.2-7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
This antibody is predicted to react with Monkey, Mouse and Rat.
Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and the performance remain unchanged.
靶标信息
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 2SH2 domain protein; HCP; HGNC:9644; MGC14433; Mutations: 351:OK; Noonan syndrome 1; OTTHUMP00000166108; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase 2C; PTP1C; SH2 domain-containing protein tyrosine phosphatase 2; unnamed protein product
基因别名: BPTP3; CFC; JMML; METCDS; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
UniProt ID: (Human) Q06124
Entrez Gene ID: (Human) 5781
phosphotyrosine binding
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
non-membrane spanning protein tyrosine phosphatase activity
insulin receptor binding
protein binding
protein kinase binding
receptor signaling complex scaffold activity
receptor tyrosine kinase binding
cadherin binding
cell adhesion molecule binding
peptide hormone receptor binding
binding, bridging
protein tyrosine kinase binding
epidermal growth factor receptor signaling pathway
brain development
heart development
fibroblast growth factor receptor signaling pathway
cytokine-mediated signaling pathway
T cell costimulation
positive regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of chondrocyte differentiation
negative regulation of type I interferon production
positive regulation of interferon-beta production
positive regulation of tumor necrosis factor production
negative regulation of cell adhesion mediated by integrin
peptidyl-tyrosine dephosphorylation
atrioventricular canal development
ERBB signaling pathway
negative regulation of T cell proliferation
vasodilation
regulation of protein complex assembly
positive regulation of ossification
positive regulation of glucose import
positive regulation of insulin receptor signaling pathway
ephrin receptor signaling pathway
genitalia development
inner ear development
negative regulation of antigen receptor-mediated signaling pathway
negative regulation of T cell receptor signaling pathway
negative regulation of T cell activation
positive regulation of protein kinase B signaling
face morphogenesis
regulation of type I interferon-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade
cellular response to mechanical stimulus
cellular response to epidermal growth factor stimulus
positive regulation of intracellular signal transduction
negative regulation of neutrophil activation
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