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Proteintech
SLC26A7 Polyclonal Antibody
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产品信息
17654-1-AP
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
SLC26A7 fusion protein Ag11901
偶联物
形式
Liquid
浓度
0.25 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Immunogen sequence: IAIVIGRFPR AMTVSIKNMK EMEFKVKTEM DSETLQQVKI ISINNPLVFL NAKKFYTDLM NMIQKENACN QPLDDISKCE QNTLLNSLSN GNCNEEASQS CPNEKCYLIL DCSGFTFFDY SGVSMLVEVY MDCKGRSVDV LLAHCTASLI KAMTYYGNLD SEKPIFFESV SAAISHIHSN KNLSKLSDHS EV
靶标信息
SLC26A7 (solute carrier family 26 member 7) is a chloride-base exchanger and/or chloride transporter that is expressed on basolateral membrane of acid-secreting cells in renal outer medullary collecting duct (OMCD) and in gastric parietal cells also. SLC26A7 belongs to conserved family of anion transporters SLC26 isoforms which display tissue-specific expression patterns in epithelial cells and several SLC26 members function as chloride/bicarbonate exchangers that include SLC26A3 (DRA), SLC26A4 (pendrin), SLC26A6 (PAT1 or CFEX), SLC26A7, and SLC26A9 among which SLC26A7 and SLC26A9 also function as chloride channels. In renal tissues, Slc26a7 co-localizes with AE1, a well-known Cl-/HCO3- exchanger, on the basolateral membrane of (acid-secreting) A-intercalated cells in OMCD cells, and in the gastric tissue, SLC26A7 co-localizes with AE2, a major Cl-/HCO3- exchanger, on the basolateral membrane of acid secreting parietal cells. SLC26A7 acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. SLC26A7 maintains the electrolyte/acid-base homeostasis in kidneys by acting as a distal excretory segment-specific anion exchanger, specifically chloride, and plays a major role in gastric acid secretion.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Anion exchange transporter; anion exchanger Slc26a7; MGC30955; RP23-272I16.1; SLC26A7; solute carrier family 26 (anion exchanger), member 7; Solute carrier family 26 member 7; solute carrier family 26, member 7; sulfate anion transporter
基因别名: SLC26A7; SUT2
UniProt ID: (Human) Q8TE54, (Mouse) Q8R2Z3
Entrez Gene ID: (Human) 115111, (Rat) 297910, (Mouse) 208890
chloride channel activity
secondary active sulfate transmembrane transporter activity
bicarbonate transmembrane transporter activity
sulfate transmembrane transporter activity
anion:anion antiporter activity
oxalate transmembrane transporter activity
anion channel activity
anion transmembrane transporter activity
transporter
gastric acid secretion
ion transport
anion transport
chloride transport
sulfate transport
bicarbonate transport
oxalate transport
regulation of membrane potential
regulation of intracellular pH
sulfate transmembrane transport
chloride transmembrane transport
inorganic anion transport
ion transmembrane transport
transport
transmembrane transport
anion transmembrane transport
organic acid transmembrane transport
