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Invitrogen
SLC6A8 Polyclonal Antibody
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SLC6A8 Antibody (PA5-111839) in IHC (F)
Immunohistochemistry analysis of SLC6A8 in perfusion-fixed, frozen rat hippocampus and cortex tissue sections using SLC6A8 Antibody (Product # PA5-111839) at a dilution of 1:200, followed by goat anti-rabbit-AlexaFluor-488. A) Creatine transporter staining (green) in the hippocampal CA1 region is detected in apical dendrites (arrows). B) Creatine transporter immunoreactivity (green) in cortex is observed in... View More
产品信息
PA5-111839
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide corresponding to amino acid residues 46-60 of rat creatine transporter (Extracellular, C-terminus)
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
保存条件
-20°C
运输条件
Wet ice
RRID
产品详细信息
Reconstitute antibody with 50 µL of double distilled water (DDW). The reconstituted solution can be stored at 4 degrees C for up to 1 week. For longer periods, small aliquots should be stored at -20 degrees C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Peptide sequence is: (C)RLAVPPR ETWTRQMD
Homology: Mouse, human amino acid residues are identical.
靶标信息
SLC6A8 (solute carrier family 6 member 8), also known as CT1 (creatine transporter 1), CRT or CRTR, is a 635 amino acid multi-pass plasma membrane protein that belongs to the sodium/neurotransporter (SNF) family. Expressed in a variety of tissues including kidney, skeletal muscle, heart, brain, prostate, testis and colon, SLC6A8 functions to transport creatine into and out of cells, specifically those found in brain and muscle tissue. Creatine, an organic acid, occurs naturally and is essential for supplying the energy needed for proper muscle and nerve function. Defects in the gene encoding SLC6A8 lead to cerebral creatine deficiency and are the cause of X-linked creatine deficiency syndrome, a rare disorder characterized by facial anomalies, seizures and mental retardation. Multiple isoforms of SLC6A8 exist due to alternative splicing events.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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