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Abnova
SMAD6 Monoclonal Antibody (2E4)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00004091-M08
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
2E4
抗原
SMAD6 (NP_005576, 285 a.a. approximately 384 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: RDEYKPLDLS DSTLSYTETE ATNSLITAPG EFSDASMSPD ATKPSHWCSV AYWEHRTRVG RLYAVYDQAV SIFYDLPQGS GFCLGQLNLE QRSESVRRTR
靶标信息
SMAD6 (mothers against decapentaplegic homolog 6) is an antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MAD homolog 6; mothers against decapentaplegic, drosophila, homolog of, 6; SMAD; SMAD family member; SMAD SMAD; SMAD, mothers against DPP homolog 6
基因别名: AOVD2; HsT17432; MADH6; MADH7
UniProt ID: (Human) O43541
Entrez Gene ID: (Human) 4091
transcription regulatory region sequence-specific DNA binding
chromatin binding
protein binding
ubiquitin protein ligase binding
type I transforming growth factor beta receptor binding
identical protein binding
co-SMAD binding
I-SMAD binding
R-SMAD binding
activin receptor binding
type I activin receptor binding
protein sequestering activity
transcription regulator inhibitor activity
protein binding, bridging involved in substrate recognition for ubiquitination
ureteric bud development
outflow tract septum morphogenesis
aortic valve morphogenesis
mitral valve morphogenesis
pulmonary valve morphogenesis
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
immune response
zygotic specification of dorsal/ventral axis
negative regulation of cell proliferation
anatomical structure morphogenesis
cell differentiation
negative regulation of ossification
BMP signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of BMP signaling pathway
cell-substrate adhesion
response to lipopolysaccharide
negative regulation of activin receptor signaling pathway
negative regulation of MyD88-dependent toll-like receptor signaling pathway
response to laminar fluid shear stress
negative regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
response to estrogen
fat cell differentiation
negative regulation of cell differentiation
negative regulation of osteoblast differentiation
negative regulation of SMAD protein import into nucleus
SMAD protein signal transduction
cellular response to growth factor stimulus
transforming growth factor beta receptor superfamily signaling pathway
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
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