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Invitrogen
SMC1B Polyclonal Antibody
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产品信息
PA5-51590
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.10 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: KSTMQILSVQ AEENCLQTVN ELMAKQQQLK DIRVTQNSSA EKVQTQIEEE RKKFLAVDRE VGKLQKEVVS IQTSLEQKRL EKHNLLLDCK VQDIEIILLS GSLDDIIEVE MGTEAESTQA TIDIYEKEEA FEIDYSSL
Highest antigen sequence identity to the following orthologs: Mouse - 66%, Rat - 67%.
靶标信息
The SMC1B gene encodes a meiosis-specific subunit of the cohesin complex, which is essential for proper chromosome segregation during meiosis. It plays a critical role in sister chromatid cohesion and DNA recombination. The SMC1B protein, also known as SMC1 beta, forms a heterodimer with SMC3, which is necessary for the formation of the cohesin complex that holds sister chromatids together until anaphase. Studies have demonstrated that SMC1B is required for the activation of the spindle assembly checkpoint (SAC) during oocyte meiosis. The loss of SMC1B function leads to improper chromosome alignment and segregation, resulting in infertility due to meiotic arrest. Furthermore, the gene is expressed exclusively during meiosis, and mutations or deletions within SMC1B can cause sterility due to disruptions in meiotic progression.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bK268H5; bK268H5.5; mitosis-specific chromosome segregation protein like protein beta; RP1-102D24.3; SMC protein 1B; SMC-1-beta; SMC-1B; SMC1 (structural maintenance of chromosomes 1, yeast)-like 1; SMC1 structural maintenance of chromosomes 1-like 2; Structural maintenance of chromosomes protein 1B
基因别名: SMC1B; SMC1BETA; SMC1L2
UniProt ID: (Human) Q8NDV3
Entrez Gene ID: (Human) 27127
