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Invitrogen
SMC1B Polyclonal Antibody
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SMC1B Antibody (PA5-88855) in WB
Western blot analysis of SMC1B in extracts of Rat testis. Samples were incubated with SMC1B Polyclonal antibody (Product # PA5-88855) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
产品信息
PA5-88855
产品规格
种属反应
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1012-1161 of human SMC1B (NP_0012784301)
偶联物
形式
Liquid
浓度
1.52 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: ILLKTAAPNL RALENLKTVR DKFQESTDAF EASRKEARLC RQEFEQVKKR RYDLFTQCFE HVSISIDQIY KKLCRNNSAQ VSSYIKEQTQ DQFQMIVISL KEEFYSRADA LIGIYPEYDD CMFSRVLTLD LSQYPDTEGQ ESSKRHGESR; Positive Samples: Rat testis; Cellular Location: Chromosome, Nucleus, centromere
靶标信息
The SMC1B gene encodes a meiosis-specific subunit of the cohesin complex, which is essential for proper chromosome segregation during meiosis. It plays a critical role in sister chromatid cohesion and DNA recombination. The SMC1B protein, also known as SMC1 beta, forms a heterodimer with SMC3, which is necessary for the formation of the cohesin complex that holds sister chromatids together until anaphase. Studies have demonstrated that SMC1B is required for the activation of the spindle assembly checkpoint (SAC) during oocyte meiosis. The loss of SMC1B function leads to improper chromosome alignment and segregation, resulting in infertility due to meiotic arrest. Furthermore, the gene is expressed exclusively during meiosis, and mutations or deletions within SMC1B can cause sterility due to disruptions in meiotic progression.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bK268H5; bK268H5.5; RP1-102D24.3; SMC; SMC-1-beta; SMC-1B; structural maintenace of chromosomes 1B; structural maintenance of chromosomes protein 1B
基因别名: Smc1l2
Entrez Gene ID: (Rat) 300121
