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Proteintech
SMC5 Monoclonal Antibody (1H6E2)
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产品信息
68655-1-IG
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
1H6E2
抗原
SMC5 fusion protein Ag5385
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Immunogen sequence: KLVTELTNLI KICTSLHIQK VDLILQNTTV ISEKNKLESD YMAASSQLRL TEQHFIELDE NRQRLLQKCK ELMKRARQVC NLGAEQTLPQ EYQTQVPTIP NGHNSSLPMV FQDLPNTLDE IDALLTEERS RASCFTGLNP TIVQEYTKRE EEIEQLTEEL KGKKVELDQY RENISQVKER WLNPLKELVE KINEKFSNFF SSMQCAGEVD LHTENEEDYD KYGIRIRVKF RSSTQLHELT PHHQSGGERS VSTMLYLMAL QELNRCPFRV VDEINQGMDP INERRVFEMV VNTACKENTS QYFFITPKLL QNLPYSEKMT VLFVYNGPHM LEPNTWNLKA FQRRRRRITF TQPS
靶标信息
Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hSMC5; MLZ-453; Protein expressed in male leptotene and zygotene spermatocytes 453; SMC protein 5; SMC-5; SMC5 structural maintenance of chromosomes 5-like 1; Structural maintenance of chromosomes protein 5; unnamed protein product
基因别名: ATELS2; KIAA0594; mKIAA0594; MLZ-453; mSMC5; SMC-5; SMC5; SMC5L1
UniProt ID: (Human) Q8IY18, (Mouse) Q8CG46
Entrez Gene ID: (Human) 23137, (Mouse) 226026, (Rat) 293967
telomere maintenance via recombination
double-strand break repair via homologous recombination
DNA repair
DNA recombination
cellular response to DNA damage stimulus
cell cycle
mitotic nuclear division
positive regulation of maintenance of mitotic sister chromatid cohesion
positive regulation of mitotic metaphase/anaphase transition
cell division
cellular senescence
double-strand break repair via nonhomologous end joining
double-strand break repair
chromosome segregation
protein sumoylation
stem cell population maintenance
chromosome condensation
regulation of telomere maintenance
mitotic cell cycle phase transition
negative regulation by host of viral genome replication
chromosome organization
positive regulation of chromosome segregation
protein localization to chromosome, centromeric region
chromatin looping
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