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Proteintech
SMTN Polyclonal Antibody
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产品信息
23567-1-AP
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
SMTN Fusion Protein Ag19983 (458-811 aa encoded by BC034237)
偶联物
形式
Liquid
浓度
0.33 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: KTTFTIEIK DGRGQASTGR VLLPTGNQRA ELTLGLRAPP TLLSTSSGGK STITRVNSPG TLARLGSVTH VTSFSHAPPS SRGGCSIKME PEPAEPLAAA VEAANGAEQT RVNKAPEGRS PLSAEELMTI EDEGVLDKML DQSTDFEERK LIRAALRELR QRKRDQRDKE RERRLQEARG RPGEGRGNTA TETTTRHSQR AADGSAVSTV TKTERLVHSN DGTRTARTTT VESSFVRRSE NGSGSTMMQT KTFSSSSSSK KMGSIFDRED QASPRAGSLA ALEKRQAEKK KELMKAQSLP KTSASQARKA MIEKLEKEGA AGSPGGPRAA VQRSTSFGVP NANSIKQMLL DWCRA (458-811 aa encoded by BC034237)
靶标信息
Smoothelin is a constituent of the smooth muscle cell (SMC) cytoskeleton. Antibodies directed to smoothelin are a useful tool to monitor SMC differentiation. Smoothelin is exclusively expressed in fully differentiated (contractile) SMCs. RNA and protein analyses reveal a broad species distribution of this protein. Cells with SMC-like characteristics, such as myofibroblasts, myoepithelial cells, and skeletal and cardiac muscle do not contain smoothelin. Confocal scanning laser microscopy of tissue sections, as well as transfection studies, show a filamentous organization of smoothelin that is different from that of desmin and vimentin. Smoothelin colocalizes with actin stress fibers. Two tissue specific isoforms have been identified: a 59 kDa isoform specific for visceral SMC; and a 100 kDa specific for vascular SMC. Human smoothelin is encoded by a single copy gene which is located on chromosome 22.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: FLJ35365; FLJ38597; Smoothelin
基因别名: SMSMO; SMTN
UniProt ID: (Human) P53814, (Mouse) Q921U8
Entrez Gene ID: (Human) 6525, (Mouse) 29856
