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Proteintech
SMURF2 Polyclonal Antibody
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产品信息
18038-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein
偶联物
形式
Liquid
纯化类型
Antigen affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Immunogen sequence: AGHCRIEVSR EEIFEESYRQ VMKMRPKDLW KRLMIKFRGE EGLDYGGVAR EWLYLLSHEM LNPYYGLFQY SRDDIYTLQI NPDSAVNPEH LSYFHFVGRI MGMAVFHGHY IDGGFTLPFY KQLLGKSITL DDMELVDPDL HNSLVWILEN DITGVLDHTF CVEHNAYGEI IQHELKPNGK SIPVNEENKK EYVRLYVNWR FLRGIEAQFL ALQKGFNEVI PQHLLKTFDE KELELIICGL GKIDVNDWKV NTRLKHCTPD SNIVKWFWKA VEFFDEERRA RLLQFVTGSS RVPLQGFKAL QGAAGPRLFT IHQIDACTNN LPKAHTCFNR IDIPPYESYE KLYEKLLTAI EETCGFAVE
靶标信息
SMURF2 is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. This protein interacts with SMAD1, SMAD2 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. It enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: E3 ubiquitin ligase SMURF2; E3 ubiquitin-protein ligase SMURF2; HECT-type E3 ubiquitin transferase SMURF2; hSMURF2; SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2
基因别名: 2810411E22Rik; AI558114; AI649275; RGD1310067; SMURF2
UniProt ID: (Human) Q9HAU4, (Mouse) A2A5Z6
Entrez Gene ID: (Human) 64750, (Rat) 303614, (Mouse) 66313
ubiquitin-protein transferase activity
transforming growth factor beta receptor binding
protein binding
ligase activity
identical protein binding
SMAD binding
ubiquitin protein ligase activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
ubiquitin-protein ligase
negative regulation of transcription from RNA polymerase II promoter
protein polyubiquitination
ubiquitin-dependent protein catabolic process
regulation of transforming growth factor beta receptor signaling pathway
BMP signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
ubiquitin-dependent SMAD protein catabolic process
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of transcription, DNA-templated
Wnt signaling pathway, planar cell polarity pathway
positive regulation of canonical Wnt signaling pathway
positive regulation of trophoblast cell migration
transforming growth factor beta receptor signaling pathway
protein ubiquitination
