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Invitrogen
SNX2 Polyclonal Antibody
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产品信息
PA1-27870
产品规格
宿主/亚型
Chicken
/ IgY
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to human Sorting nexin-2.
偶联物
形式
Liquid
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
PA1-27870 detects SNX2 from human, mouse, and rat samples.
PA1-27870 may be successfully used in Western blot applications. By Western blot, this antibody has only been tested on fusion protein.
The immunogen is a synthetic peptide corresponding to human Sorting nexin-2.
靶标信息
Sorting nexin 2 (SNX2) is a gene located on human chromosome 5q23.3 that encodes a protein involved in various cellular processes, primarily associated with endosomal sorting and intracellular trafficking. SNX2, along with SNX1, forms part of the sorting nexin family characterized by the presence of a Phox (PX) domain, which binds phosphoinositides and facilitates the interaction with membrane compartments such as endosomes. Functionally, SNX2 plays roles in the retrograde transport of Shiga toxin from endosomes to the Golgi apparatus, as well as regulation of endosome-endoplasmic reticulum contact sites through interaction with VAP proteins at the ER membrane. Additionally, SNX2 is implicated in autophagy initiation during nutrient starvation by facilitating the tubulation of early endosomes toward ER sites. As a membrane-associated protein, SNX2 is essential for protein trafficking and retrieval of transmembrane proteins, thus contributing to cellular homeostasis and the dynamic remodeling of endosomal zones.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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