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PA1-18278 detects Superoxide Dismutase 3 from human samples.
PA1-18278 has been successfully used in immunohistochemistry (paraffin and frozen) and Western blot procedures.
The PA1-18278 immunogen is a synthetic peptide corresponding to residues W(18)T G E D S A E P N S D S A E W I R D(37) of human extracellular superoxide dismutase (SOD3), conjugated to diphtheria toxin.
Reconstitute with 100 µL of distilled water.
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.
仅用于科研。不用于诊断过程。未经明确授权不得转售。