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Proteintech
SPDEF Monoclonal Antibody (2A1C1)
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产品信息
68716-1-IG
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
2A1C1
抗原
SPDEF fusion protein Ag33739
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Immunogen sequence: MGSASPGLSS VSPSHLLLPP DTVSRTGLEK AAAGAVGLER RDWSPSPPAT PEQGLSAFYL SYFDMLYPED SSWAAKAPGA SSREEPPEEP EQCPVIDSQA PAGSLDLVPG GLTLEEHSLE QVQSMVVGEV LKDIETACKL LNITADPMDW SPSNVQKWLL WTEHQYRLPP MGKAFQELAG KELCAMSEEQ FRQRSPLGGD VLHAHLDIWK SAAWMKERTS PGAIHYCAST SEESWTDSEV DSSCSGQPIH LWQFLKELLL KPHSYGRFIR WLNKEKGIFK IEDSAQVARL WGIRKNRPAM NYDKLSRSIR QYYKKGIIRK PDISQRLVYQ FVHPI
靶标信息
PDEF (prostate-derived Ets factor) is a 37.5-kDa protein that acts as an androgen-independent transcriptional activator for the PSA (prostate specific antigen) promoter. It also interacts directly with the DNA binding domain of androgen receptor and enhances androgen-mediated activation of the PSA promoter. PDEF was shown to have transcript levels 192-fold higher in the peripheral blood of some breast cancer patients in comparison with normal individuals. PDEF mRNA is also frequently over-expressed in human breast tumors as well as in human ovarian tumors. In ovarian tumors, PDEF expression seems to down-modulate malignant potential, and thus provides a rationale to screen for drugs that induce PDEF expression in epithelial ovarian tumors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Prostate epithelium-specific Ets transcription factor; Prostate-derived Ets factor; Prostate-specific Ets; SAM pointed domain-containing Ets transcription factor
基因别名: bA375E1.3; PDEF; PSE; SPDEF
UniProt ID: (Human) O95238
Entrez Gene ID: (Human) 25803
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
multicellular organism development
negative regulation of cell fate commitment
positive regulation of cell fate commitment
cell differentiation
positive regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
lung goblet cell differentiation
intestinal epithelial cell development
