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Invitrogen
SPOCK2 Polyclonal Antibody
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SPOCK2 Antibody (PA5-48009) in WB
Western blot analysis of SPOCK2 in rat lung tissue. Samples were incubated in SPOCK2 polyclonal antibody (Product # PA5-48009) using a dilution of 1 µg/mL followed by a HRP-conjugated Anti-Goat IgG secondary antibody. A specific band was detected for Testican 2/SPOCK2 at approximately 140 kDa (as indicated). This experiment was conducted under reducing conditions.
产品信息
PA5-48009
产品规格
种属反应
Mouse,
Rat,
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Mouse myeloma cell line NS0-derived recombinant human Testican 2/SPOCK2 Glu23-Trp424
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody detects human, mouse, and rat Testican 2/SPOCK2 in direct ELISAs and human Testican 2/SPOCK2 in Western blots.
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
The SPOCK2 gene encodes the protein testican-2, a member of the SPARC (secreted protein acidic and rich in cysteine) family of extracellular matrix (ECM) proteins. SPOCK2 is involved in modulating the ECM environment, influencing cell-matrix interactions, tissue remodeling, and cellular communication. It plays a role in the regulation of proteolytic activity by inhibiting metalloproteinases, thereby contributing to the maintenance and integrity of the ECM. SPOCK2 is prominently expressed in the brain and testes, highlighting its involvement in neural development and reproductive biology. In neural tissues, it influences processes such as neuronal differentiation, synaptogenesis, and axonal guidance, which are critical for proper brain development and function. Dysregulation of SPOCK2 expression is associated with pathological conditions, including cancer, where it may impact tumor progression and metastasis through alterations in cell adhesion and migration. Research into SPOCK2's specific interactions and mechanisms continues, providing insights into its potential as a therapeutic target for managing ECM-related disorders and diseases involving abnormal cell-matrix interactions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ97039; granule cell antiserum positive 26; KIAA0275CWCV; sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2; SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2; Testican-2
基因别名: AA407235; Gcap26; KIAA0275; mKIAA0275; SPOCK2; testican-2; TICN2; UNQ269/PRO306
UniProt ID: (Human) Q92563, (Mouse) Q9ER58
Entrez Gene ID: (Human) 9806, (Rat) 361840, (Mouse) 94214
