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Proteintech
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Immunogen sequence: ITKNGESIM VELAAGPFGN NEKLPVVIRV PKLIYFSVMS VCLMPVSILG FGDIIVPGLL IAYCRRFDVQ TGSSYIYYVS STVAYAIGMI LTFVVLVLMK KGQPALLYLV PCTLITASVV AWRRKEMKKF WKGNSYQMMD HLDCATNEEN PVISGEQIVQ Q (361-520 aa encoded by BC025740)
By searching sequence databases for homologs of Dictyostelium discoideum Impas, which shares homology with presenilin, followed by PCR of lymphocyte and hippocampus cDNA libraries, Grigorenko et al. (2002) cloned SPPL2a. This protein, which may act as an intramembrane protease, contains an N-terminal protease-associated (PA) domain, several transmembrane regions, a hydrophilic loop, conservative sequences around the first and second aspartate residues, and an invariant PAL motif near the C terminus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: IMP-3; IMPAS; intramembrane cleaving protease; intramembrane protease 3; presenilin-like protein 2; protein SPPL2a; SPP-like 2A; SPP-like 2A protein; SPPL2a protein; unnamed protein product
基因别名: 2010106G01Rik; C130089K23Rik; IMD86; IMP3; PSL2; RGD1563001
UniProt ID: (Human) Q8TCT8, (Mouse) Q9JJF9
Entrez Gene ID: (Human) 84888, (Rat) 311401, (Mouse) 66552