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SREBP-1/2 Polyclonal Antibody

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说明书
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说明书
Certificates
实验方案
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技术支持
说明书
Certificates
实验方案
问题与答案
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产品信息

BS-1402R

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:300
-

免疫组化（石蜡） (IHC (P))

1:200
-

免疫组化（冰冻） (IHC (F))

1:100-1:500
-

免疫细胞化学 (ICC/IF)

1:50-1:200
-

酶联免疫吸附实验 (ELISA)

1:500-1:1,000
-
产品规格

种属反应

Bovine, Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide derived from human SREBP-1.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

规格

100 µg

纯化类型

Protein A

保存液

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

内含物

0.02% ProClin 300

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Isoform SREBP-1A is much more active than isoform SREBP-1C in stimulating transcription from SRE-1-containing promoters. [SUBUNIT] Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. [SUBCELLULAR LOCATION] Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols. [SUBCELLULAR LOCATION] Processed sterol regulatory element-binding protein 1: Nucleus. Belongs to the SREBP family.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Cite this product

生物信息学

蛋白别名: adipocyte determination and differentiation-dependent factor 1; adipocyte determination- and differentiation-dependent factor 1; class D basic helix-loop-helix protein 1; class D basic helix-loop-helix protein 2; SREBF2; sterol regulatory element binding factor 2; sterol regulatory element-binding transcription factor 2; sterol response element binding protein 1; unnamed protein product

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基因别名: ADD-1; ADD1; bHLHd1; bHLHd2; HMD; IFAP2; lop13; nuc; Srebf2_retired; SREBP-1; SREBP-1c; SREBP-2; SREBP1; SREBP2; SREBP2gc

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UniProt ID: (Human) P36956, (Human) Q12772, (Rat) P56720, (Mouse) Q9WTN3, (Mouse) Q3U1N2, (Rat) Q3T1I5

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Entrez Gene ID: (Human) 6720, (Bovine) 539361, (Bovine) 507102, (Human) 6721, (Rat) 78968, (Mouse) 20787, (Mouse) 20788, (Rat) 300095

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功能
RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription cofactor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding protein kinase binding sterol response element binding sequence-specific DNA binding macromolecular complex binding protein dimerization activity sequence-specific double-stranded DNA binding C-8 sterol isomerase activity transcription regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding E-box binding
参与通路
regulation of transcription from RNA polymerase II promoter lipid metabolic process response to nutrient circadian rhythm cholesterol metabolic process lipid biosynthetic process cellular response to starvation response to xenobiotic stimulus response to fructose positive regulation of triglyceride biosynthetic process lung development intracellular receptor signaling pathway regulation of protein stability response to food response to retinoic acid response to progesterone cellular response to insulin stimulus SREBP signaling pathway response to glucagon response to lipid response to peptide hormone response to ethanol positive regulation of cholesterol biosynthetic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter response to cAMP response to fatty acid cellular response to fatty acid negative regulation of triglyceride metabolic process regulation of mitophagy positive regulation of pri-miRNA transcription from RNA polymerase II promoter regulation of protein localization to mitochondrion negative regulation of transcription from RNA polymerase II promoter regulation of heart rate by chemical signal regulation of transcription, DNA-templated insulin receptor signaling pathway response to glucose regulation of fatty acid metabolic process response to insulin mRNA transcription from RNA polymerase II promoter positive regulation of innate immune response fat cell differentiation negative regulation of insulin secretion positive regulation of lipid biosynthetic process regulation of insulin secretion positive regulation of fatty acid biosynthetic process regulation of Notch signaling pathway positive regulation of cholesterol storage cellular response to low-density lipoprotein particle stimulus cellular response to laminar fluid shear stress negative regulation of cholesterol efflux negative regulation of beta-amyloid clearance positive regulation of establishment of protein localization to mitochondrion response to hormone cholesterol homeostasis spermatogenesis response to lead ion
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