Search
Search
Invitrogen
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Immunogen sequence: PSSPTENGTE NQPKFGSKST LEENAYEDIV GDLPKENPYE DVDLKSRRAG RKSQQLSENS LDSLHRMWSP QDRKYNSPPT QLSLKPNSQS LRSGNWSERK
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 65%.
This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: DENN/MADD domain containing 2B; heLa tumor suppression 1; p70; suppression of tumorigenicity 5 protein; unnamed protein product
基因别名: HTS1; p126; ST5
UniProt ID: (Human) P78524
Entrez Gene ID: (Human) 6764