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Invitrogen
STAT5 alpha/beta Polyclonal Antibody
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产品信息
OPA1-03010
应用
建议稀释比
已发表文章
产品规格
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic Peptide derived from an internal region of human STAT5.
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
产品详细信息
OPA1-03010 detects signal transducer and activator of transcription 5 a/b (STAT5) from human, mouse, and hamster tissues and cells. Rat tissues are expected to react based on sequence homology. This antibody is specific for STAT5 and does not cross-react with any other STATs or related proteins. OPA1-03010 has been successfully used in western blot procedures. By western blot, this antibody detects an ~92 and ~85 kDa protein representing STAT5a and STAT5b, respectively, from CTLL cell lysate. OPA1-03010 was raised against a synthetic peptide derived from an internal region of human STAT5. The sequence of the immunogen is identical in rat.
靶标信息
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of, many cell ligands, such as IL-2, IL-3, IL-7, GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/ BCL-X(L), which suggests the antiapoptotic function of this gene in cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
