Proteintech

STRAP Polyclonal Antibody

Name: STRAP Polyclonal Antibody
Brand: Proteintech
SKU: 18277-1-AP

12 篇参考文献

查看其他10个STRAP抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (20)

STRAP Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 20

STRAP Antibody (18277-1-AP) in ICC/IF

Immunofluorescent analysis of ( 4% PFA ) fixed HeLa cells using 18277-1-AP (STRAP antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

STRAP Antibody in Immunohistochemistry (Paraffin) (IHC (P))

STRAP Antibody in Immunoprecipitation (IP)

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Immunogen image

Immunogen Image STRAP Polyclonal Antibody

产品信息

18277-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:4,000

查看7篇已发表文章 7篇已发表文章

免疫组化 (IHC)

查看1篇已发表文章 1篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:200

免疫细胞化学 (ICC/IF)

1:50-1:500

查看1篇已发表文章 1篇已发表文章

免疫沉淀 (IP)

0.5-4.0 µg

查看2篇已发表文章 2篇已发表文章

不适用 (N/A)

查看1篇已发表文章 1篇已发表文章

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

STRAP Fusion Protein Ag13085 (1-350 aa encoded by BC000162)

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.31 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MAMRQTPLT CSGHTRPVVD LAFSGITPYG YFLISACKDG KPMLRQGDTG DWIGTFLGHK GAVWGATLNK DATKAATAAA DFTAKVWDAV SGDELMTLAH KHIVKTVDFT QDSNYLLTGG QDKLLRIYDL NKPEAEPKEI SGHTSGIKKA LWCSEDKQIL SADDKTVRLW DHATMTEVKS LNFNMSVSSM EYIPEGEILV ITYGRSIAFH SAVSLDPIKS FEAPATINSA SLHPEKEFLV AGGEDFKLYK YDYNSGEELE SYKGHFGPIH CVRFSPDGEL YASGSEDGTL RLWQTVVGKT YGLWKCVLPE EDSGELAKPK IGFPETTEEE LEEIASENSD CIFPSAPDVK A (1-350 aa encoded by BC000162)

靶标信息

STRAP is a 350 amino acid MAP activator with WD-40 repeats that is localized both in the cytoplasm and the nucleus. It is a ubiquitously expressed protein that acts as an inhibitor of TGF-beta signaling and an important regulator of cell proliferation. Stable expression of STRAP results in activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and in down-regulation of the cyclin-dependent kinase inhibitor p21 (Cip1), which results in retinoblastoma protein hyperphosphorylation. Upregulation of STRAP might play a role in tumor development as an early event for colorectal cancers. It is the first component of the U snRNP assembly machinery that associates with SMN complex in a compartment-specific way and plays a crucial role in the intracellular distribution of SMN1.

仅用于科研。不用于诊断过程。未经明确授权不得转售。