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Invitrogen
STRAP Polyclonal Antibody
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产品信息
PA5-55583
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: AFSGITPYGY FLISACKDGK PMLRQGDTGD WIGTFLGHKG AVWGATLNKD ATKAATAAAD FTAKVWDAVS GDELMTL
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
靶标信息
STRAP is a 350 amino acid MAP activator with WD-40 repeats that is localized both in the cytoplasm and the nucleus. It is a ubiquitously expressed protein that acts as an inhibitor of TGF-beta signaling and an important regulator of cell proliferation. Stable expression of STRAP results in activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and in down-regulation of the cyclin-dependent kinase inhibitor p21 (Cip1), which results in retinoblastoma protein hyperphosphorylation. Upregulation of STRAP might play a role in tumor development as an early event for colorectal cancers. It is the first component of the U snRNP assembly machinery that associates with SMN complex in a compartment-specific way and plays a crucial role in the intracellular distribution of SMN1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MAP activator with WD repeats; Serine-threonine kinase receptor-associated protein; UNR-interacting protein; WD-40 repeat protein PT-WD
基因别名: AW557906; C78091; C79202; MAWD; PT-WD; STRAP; UNRIP
UniProt ID: (Human) Q9Y3F4, (Mouse) Q9Z1Z2, (Rat) Q5XIG8
Entrez Gene ID: (Human) 11171, (Mouse) 20901, (Rat) 297699
negative regulation of transcription from RNA polymerase II promoter
spliceosomal snRNP assembly
negative regulation of epithelial cell migration
negative regulation of epithelial to mesenchymal transition
maintenance of gastrointestinal epithelium
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of epithelial cell proliferation
negative regulation of pathway-restricted SMAD protein phosphorylation
mRNA processing
RNA splicing
