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Abnova
STX1A Polyclonal Antibody, MaxPab™
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00006804-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
STX1A (AAH03011.1, 1 a.a. approximately 251 a.a) full-length human protein.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.34 mg/mL
规格
50 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MKDRTQELRT AKDSDDDDDV AVTVDRDRFM DEFFEQVEEI RGFIDKIAEN VEEVKRKHSA ILASPNPDEK TKEELEELMS DIKKTANKVR SKLKSIEQSI EQEEGLNRSS ADLRIRKTQH STLSRKFVEV MSEYNATQSD YRERCKGRIQ RQLEITGRTT TSEELEDMLE SGNPAIFASG IIMDSSISKQ ALSEIETRHS EIIKLENSIR ELHDMFMDMA MLVESQTMWR GPCLTPRRPS STRARRAGRK S
靶标信息
Syntaxin 1 is a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: neuron-specific antigen HPC-1; STX1A; STX1B; STX1B1; STX1B2; STXA1; syntaxin 1A (brain); Syntaxin-1B1; Syntaxin-1B2; unnamed protein product
基因别名: HPC-1; P35-1; STX1; SYN1A
UniProt ID: (Human) Q16623
Entrez Gene ID: (Human) 6804
SNARE binding
SNAP receptor activity
protein binding
myosin binding
calcium channel inhibitor activity
chloride channel inhibitor activity
kinase binding
protein binding, bridging
myosin head/neck binding
identical protein binding
ATP-dependent protein binding
ion channel binding
macromolecular complex binding
calcium-dependent protein binding
protein carrier chaperone
positive regulation of neurotransmitter secretion
intracellular protein transport
exocytosis
vesicle fusion
neurotransmitter secretion
response to gravity
positive regulation of norepinephrine secretion
regulation of synaptic vesicle priming
synaptic vesicle exocytosis
vesicle-mediated transport
protein sumoylation
regulation of exocytosis
insulin secretion
secretion by cell
positive regulation of catecholamine secretion
SNARE complex assembly
SNARE complex disassembly
regulated exocytosis
positive regulation of exocytosis
positive regulation of calcium ion-dependent exocytosis
hormone secretion
synaptic vesicle endocytosis
regulation of insulin secretion
protein localization to membrane
modulation of excitatory postsynaptic potential
positive regulation of excitatory postsynaptic potential
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