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MA3-932 detects sarcalumenin from canine, guinea pig, mouse and rabbit tissues. This antibody specifically detects sarcalumenin and the 53 kDa glycoprotein splice variant.
MA3-932 has been successfully used in Western blot. By Western blot, this antibody detects a 53 kDa and a 160 kDa protein representing the glycoprotein and sarcalumenin, respectively, in rabbit skeletal muscle extracts.
The MA3-932 antigen is purified rabbit sarcoplasmic reticulum membrane vesicles.
Sarcalumenin is a 160 kDa acidic calcium binding glycoprotein found to reside at the inner membrane of the sarcoplasmic reticulum in a calcium dependent manner. The gene encoding sarcalumenin also encodes an alternate splice variant, a 53 kDa glycoprotein which co-localizes with sarcalumenin. These two proteins are found in the longitudinal sarcoplasmic reticulum and the nonjunctional membranes of the terminal cisternae. They have been observed to co-localize with calcium-ATPase suggesting that they are involved in calcium transport and sequestration.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Sarcalumenin; sarcolumenin; sarcolumenin precursor; sarcoplasmic reticulum glycoprotein
基因别名: 9830004M20Rik; AW108387; Sar; SRL
UniProt ID: (Rabbit) P13666, (Mouse) Q7TQ48
Entrez Gene ID: (Dog) 490030, (Rabbit) 100009112, (Mouse) 106393, (Guinea pig) 100719273, (Rat) 302948