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Invitrogen
Sirolimus Recombinant Mouse Monoclonal Antibody (4G8)
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Sirolimus Antibody (MA566318) in SDS-PAGE
SDS-PAGE characterization of Sirolimus under reducing conditions. Lane M: Protein marker (kDa); Lane SRL: Purified Sirolimus Recombinant Monoclonal (Product # MA566318). Sirolimus showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-327.
产品信息
MA566318
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
4G8
抗原
Conjugate of SRL hapten and KLH.
偶联物
形式
Liquid
浓度
11 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Sirolimus, also known as rapamycin, is a macrolide compound with potent immunosuppressive properties, primarily used to prevent organ transplant rejection. It functions by inhibiting the mechanistic target of rapamycin (mTOR), a key regulatory kinase involved in cell proliferation and survival. Sirolimus is often utilized in drug-eluting stents, such as the BioMime sirolimus-eluting stent, to prevent restenosis in coronary arteries. The drug's gene location and structure are not directly relevant, as it is a synthetic compound rather than a naturally occurring gene product. However, its mechanism of action involves binding to the FKBP12 protein, forming a complex that inhibits mTOR signaling pathways, thereby reducing T-cell and B-cell proliferation. Sirolimus has been extensively studied for its efficacy in prolonging allograft survival and reversing acute rejection in animal models, leading to its approval for clinical use in renal transplant prophylaxis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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