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Invitrogen
Sortilin (extracellular) Polyclonal Antibody
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Sortilin (extracellular) Antibody (PA5-77535) in IHC
Immunohistochemistry analysis of Sortilin (extracellular) in rat neocortex. A) Samples were probed with Sortilin (extracellular) polyclonal antibody (Product # PA5-77535) and incubated with parvalbumin (green). B) Interneurons stained image. C) Confocal merged image.
产品信息
PA5-77535
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide DKDTTRRIHVSTDQD(C) corresponding to amino acid residues 320-335 of human Sortilin
偶联物
形式
Lyophilized
浓度
0.4 mg/mL
保存条件
-20°C
运输条件
Wet ice
RRID
产品详细信息
Product is shipped at room temperature as a lyophilized powder and should be stored at -20 °C upon receipt. Reconstitution: add 50 µL of deionized water.
靶标信息
Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Sortilin is required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). It is also required for protein transport from the Golgi apparatus to the endosomes. Sortilin promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also, Sortilin acts as a receptor for neurotensin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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