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Invitrogen
Spectrin alpha-1 Polyclonal Antibody
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产品信息
PA1-25008
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Purified, full length, native chicken spectrin alpha and beta chain protein
偶联物
形式
Liquid
保存条件
-20°C or -80°C if preferred
运输条件
Wet ice
产品详细信息
PA1-25008 detects Spectrin from a wide range of avian and mammalian samples.
PA1-25008 has been successfully used in Western blot and immunofluorescence procedures. The predicted molecular weight of PA1-25008 is 220 and 240 kDa.
The PA1-25008 immunogen is purified, full length, native chicken spectrin alpha and beta chain protein.
靶标信息
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia. [provided by RefSeq, Jul 2008]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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