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Alomone Labs, LTD
Syntaxin 1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
ANR-002-200UL
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
GST fusion protein with the sequence corresponding to amino acid residues 1-265 of rat syntaxin 1A, Intracellular, N-terminus
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
0.4 mg/mL
规格
80 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Immunogen sequence: MKDRTQELRT AKDSDDDDDV TVTVDRDRFM DEFFEQVEEI RGFIDKIAEN VEEVKRKHSA ILASPNPDEK TKEELEELMS DIKKTANKVR SKLKSIEQSI EQEEGLNRSS ADLRIRKTQH STLSRKFVEV MSEYNATQSD YRERCKGRIQ RQLEITGRTT TSEELEDMLE SGNPAIFASG IIMDSSISKQ ALSEIETRHS EIIKLENSIR ELHDMFMDMA MLVESQGEMI DRIEYNVEHA VDYVERAVSD TKKAVKYQSK ARRKK
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Syntaxin 1 is a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: neuron-specific antigen HPC-1; P35A; SNARE protein; STX1B; STX1B1; STX1B2; STXA1; synaptotagmin-associated 35 kDa protein; syntaxin 1 a; syntaxin 1A (brain); syntaxin 1A (brain)-like; Syntaxin-1B1; Syntaxin-1B2
基因别名: HPC-1
UniProt ID: (Rat) P32851, (Mouse) O35526
Entrez Gene ID: (Rat) 116470, (Mouse) 20907
SNARE binding
SNAP receptor activity
protein binding
myosin binding
calcium channel inhibitor activity
chloride channel inhibitor activity
kinase binding
protein binding, bridging
myosin head/neck binding
identical protein binding
ATP-dependent protein binding
ion channel binding
macromolecular complex binding
calcium-dependent protein binding
protein carrier chaperone
positive regulation of neurotransmitter secretion
neurotransmitter transport
intracellular protein transport
exocytosis
vesicle fusion
response to gravity
positive regulation of norepinephrine secretion
regulation of synaptic vesicle priming
regulation of dopamine secretion
synaptic vesicle exocytosis
vesicle-mediated transport
protein sumoylation
calcium ion regulated exocytosis
regulation of exocytosis
insulin secretion
secretion by cell
positive regulation of catecholamine secretion
SNARE complex assembly
SNARE complex disassembly
regulated exocytosis
positive regulation of exocytosis
positive regulation of calcium ion-dependent exocytosis
hormone secretion
synaptic vesicle endocytosis
protein localization to membrane
modulation of excitatory postsynaptic potential
regulation of secretion by cell
positive regulation of excitatory postsynaptic potential
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