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Invitrogen
TAFA1 Polyclonal Antibody
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TAFA1 Antibody (PA5-48071) in IHC (P)
Immunohistochemical analysis of TAFA1 in immersion fixed paraffin-embedded sections of human brain (cortex). Samples were incubated in TAFA1 polyclonal antibody (Product # PA5-48071) using a dilution of 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Lower panel shows a lack of labeling when primary ant... View More
产品信息
PA5-48071
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived recombinant human TAFA1/FAM19A1 Ser26-Thr133
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In direct ELISAs, approximately 15% cross-reactivity with recombinant human (rh) TAFA3 and rhTAFA4 is observed, less than 10% cross-reactivity with rhTAFA2 is observed and less than 1% cross-reactivity with rhTAFA5 is observed.
Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
靶标信息
TAFA Chemokine Like Family Member 1 (TAFA1) is a gene located on chromosome 7q31.1, encoding a protein that is part of the FAM19A family, known for its role in modulating inflammation and neural development. TAFA1 is expressed in the brain where it influences brain-tissue homeostasis and neuronal signaling pathways. Functionally, TAFA1 acts as a chemokine-like protein, impacting the migration and adhesion of neuronal cells and contributing to neuroprotective activities. Its expression is implicated in maintaining neural network integrity and regulating processes such as neurogenesis and synaptic plasticity. Dysregulation of TAFA1 has been associated with neuroinflammatory conditions and neurodegenerative diseases, reflecting its importance in neural health and pathology. Research into TAFA1 aims to uncover its exact biological roles and potential as a therapeutic target in conditions involving disrupted cellular communication and inflammation in the nervous system.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Chemokine-like protein TAFA-1; family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
基因别名: FAM19A1; TAFA-1; TAFA1
UniProt ID: (Human) Q7Z5A9
Entrez Gene ID: (Human) 407738
