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Invitrogen
TAFA5 Monoclonal Antibody (463102)
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TAFA5 Antibody (MA5-24183) in IHC (P)
Immunohistochemical analysis of TAFA5 in immersion fixed paraffin-embedded sections of human cerebellum. Samples were incubated in TAFA5 monoclonal antibody (Product # MA5-24183) using a dilution of 15 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic. Tissue was stained using the Anti-Mouse HRP-... View More
产品信息
MA5-24183
产品规格
种属反应
Human
宿主/亚型
Rat
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
463102
抗原
E. coli-derived recombinant human TAFA5/FAM19A5 Gln26-Ser125
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In direct ELISAs and Western blots, no cross-reactivity with recombinant human TAFA2, 3, or 4 is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
靶标信息
Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2. Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway. Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes. Stimulation of macrophage migration and inhibition of osteoclast formation is mediated via GPCR FPR2. Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling . Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Chemokine-like protein TAFA-5; family with sequence similarity 19 (chemokine (C-C motif)-like), member A5; TAFA protein 5
基因别名: FAM19A5; QLLK5208; TAFA-5; TAFA5; UNQ5208; UNQ5208/PRO34524
UniProt ID: (Human) Q7Z5A7
Entrez Gene ID: (Human) 25817
