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Proteintech
TAPBP Polyclonal Antibody
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产品信息
30500-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
TAPBP fusion protein Ag30885
偶联物
形式
Liquid
浓度
0.75 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Immunogen sequence: GPAVIECWFV EDASGKGLAK RPGALLLRQG PGEPPPRPDL DPELYLSVHD PAGALQAAFR RYPRGAPAPH CEMSRFVPLP ASAKWASGLT PAQNCPRALD
靶标信息
This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DADB-159G18.7; NGS-17; TAP-associated protein; TAP-binding protein; Tapasin; TPN; TPSN
基因别名: D17Wsu91e; NGS17; TAPA; TAPBP; TPN; TPSN
UniProt ID: (Human) O15533, (Mouse) Q9R233
Entrez Gene ID: (Human) 6892, (Mouse) 21356
antigen processing and presentation of peptide antigen via MHC class I
protein complex assembly
retrograde vesicle-mediated transport, Golgi to ER
immune response
regulation of gene expression
antigen processing and presentation of endogenous peptide antigen via MHC class I
peptide antigen stabilization
transmembrane transport
regulation of protein complex stability
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
defense response
