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Proteintech
TBC1D23 Polyclonal Antibody
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产品信息
17002-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
TBC1D23 Fusion Protein Ag10697 (1-320 aa encoded by BC010221)
偶联物
形式
Liquid
浓度
0.25 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This antibody is specific to TBC1D23.
Immunogen sequence: MLQNPSEFA QSVKSLLEAQ KQSIESGSIA GGEHLCFMGS GREEEDMYMN MVLAHFLQKN KEYVSIASGG FMALQQHLAD INVDGPENGY GHWIASTSGS RSSINSVDGE SPNGSSDRGM KSLVNKMTVA LKTKSVNVRE KVISFIENTS TPVDRHVSSS DRVGKPYRGV KPVFSIGDEE EYDTDEIDSS SMSDDDRKEV VNIQTWINKP DVKHHFPCKE VKESGHMFPS HLLVTATHMY CLREIVSRKG LAYIQSRQAL NSVVKITSKK KHPELITFKY GNSSASGIEI LAIERYLIPN AGDATKAIKQ QIMKVLDALE S (1-320 aa encoded by BC010221)
靶标信息
Putative Rab GTPase-activating protein which plays a role in vesicular trafficking (PubMed:28823707). Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197, PubMed:29426865). Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). Plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth. May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: HCV non-structural protein 4A-transactivated protein 1; HCV nonstructural protein 4A-transactivated protein 1; TBC1 domain family member 23; TBC1 domain family, member 23
基因别名: 4930451A13Rik; AU015720; AU043671; AU043778; D030022P07Rik; NS4ATP1; RGD1307925; TBC1D23; W51689
UniProt ID: (Human) Q9NUY8, (Mouse) Q8K0F1
Entrez Gene ID: (Human) 55773, (Mouse) 67581, (Rat) 304019
