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Invitrogen
TC2N Polyclonal Antibody
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产品信息
PA5-55651
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.10 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: IKSCCGGCFY GETEKHNFSV ERDFKAAVPN SQNATISVPP LTSVSVKPQL GCTEDYLLSK LPSDGKEVPF VVPKFKLSYI QPRTQETPSH LEELEGSARA SFGDRKVELS SSSQHGPSYD VYNPFYMYQH ISPDLSRRF
Highest antigen sequence identity to the following orthologs: Mouse - 80%, Rat - 78%.
靶标信息
The TC2N gene encodes the Tandem C2 domains nuclear protein, which is characterized by the presence of two C2 domains, C2A and C2B, at the C-terminus. These domains are structured as an eight-stranded antiparallel beta-sandwich, initially recognized as a Ca2+ binding module. TC2N's role varies significantly across different types of cancer. It has been identified as an oncogene in lung, gastric, and hepatocellular carcinomas, where its overexpression promotes cell proliferation, migration, and metastasis. Conversely, in breast cancer, TC2N functions as a tumor suppressor, inhibiting distant metastasis and stemness via the PI3K-Akt signaling pathway. These dual roles highlight its complex involvement in tumorigenesis, with its impact being highly context-dependent on the cancer type.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C2 calcium-dependent domain containing 1; membrane targeting (tandem) C2 domain containing 1; Membrane targeting tandem C2 domain-containing protein 1; Tac2-N; Tandem C2 domains nuclear protein; Tandem C2 protein in nucleus
基因别名: C14orf47; C2CD1; MTAC2D1; Tac2-N; TC2N
UniProt ID: (Human) Q8N9U0
Entrez Gene ID: (Human) 123036
