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Invitrogen
TCF3 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-149382
产品规格
种属反应
Mouse
宿主/亚型
Sheep
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived recombinant mouse TCF-3/E2A, Asn33-Arg159
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
0.2 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
TCF3 (E2A) is a transcription factor that plays major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Heterodimers between E2A and tissue-specific basic helix-loop-helix (bHLH) Dimers bind DNA on E-box motifs: 5'- CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Deletions in E2A have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Two alternatively spliced human isoforms have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: E2A; immunoglobulin enhancer-binding factor E12/E47; MGC129647; MGC129648; transcription factor A1; transcription factor E2a; unnamed protein product
基因别名: A1; ALF2; bHLHb21; E12; E12/E47; E2A; E47; KA1; ME2; Pan1; Pan2; TCF-3; Tcfe2a; VDIR
UniProt ID: (Mouse) P15806
Entrez Gene ID: (Mouse) 21423
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
PDZ domain binding
mitogen-activated protein kinase kinase kinase binding
identical protein binding
protein homodimerization activity
bHLH transcription factor binding
sequence-specific DNA binding
protein heterodimerization activity
protein dimerization activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
vitamin D response element binding
E-box binding
DNA-binding transcription factor binding
negative regulation of transcription from RNA polymerase II promoter
natural killer cell differentiation
B cell lineage commitment
chromatin remodeling
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
gastrulation
response to xenobiotic stimulus
positive regulation of gene expression
lymphocyte differentiation
positive regulation of B cell proliferation
response to lipopolysaccharide
T cell differentiation in thymus
immunoglobulin V(D)J recombination
positive regulation of neuron differentiation
positive regulation of cell cycle
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cell development
Peyer's patch development
protein stabilization
regulation of G1/S transition of mitotic cell cycle
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