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Invitrogen
TCF7L2 Polyclonal Antibody
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TCF7L2 Antibody (PA5-77812) in WB
Western blot analysis of TCF7L2 in rat kidney lysate using 15 µg of protein. Sample was prepared with 5% milk and TBST, incubated with TCF7L2 polyclonal antibody (Product # PA5-77812) using a dilution of 1:1000 (2 hours at RT) and followed by a Goat Anti-Rabbit HRP secondary antibody at a dilution of 1:3000 (1 hour at RT). Samples are arranged as follows: Lane 1: molecular weight ladder, Lane 2: rat kidney lysate.
产品信息
PA5-77812
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide of Human TCF7L2 (400-500 aa), conjugated to Keyhole Limpet Haemocyanin (KLH)
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
-20°C
运输条件
Wet ice
RRID
产品详细信息
A 1:1,000 dilution of PA5-77812 was sufficient for detection of TCF7L2 in 15 µg of rat kidney cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.|Detects 68 kDa, band at approximately 55 kDa is another isoform, band at approximately 75 kDa is due to post translational modification.
靶标信息
TCF7L2, or TCF4, is a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. TCF7L2 has been implicated in glucose homeostasis through the regulation of pro-glucagon gene expression, which encodes glucagon-like peptide 1 (GLP-1). Genetic variants of TCF7L2 have been linked to type 2 diabetes, and it has specifically been shown to have an important role in the regulation of both beta-cell survival and function. Several splicing isoforms for TCF7L2 have been shown to be differentially expressed in tissues during cancer progression, and gene targeting studies indicate that TCF7L2 is required to maintain the crypt stem cells of the small intestine.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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