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Proteintech
TCIRG1 Polyclonal Antibody
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产品信息
12649-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human,
Pig
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
TCIRG1 Fusion Protein Ag3378 (25-395 aa encoded by BC018133)
偶联物
形式
Liquid
浓度
0.19 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: CVSRLGELG LVEFRDLNAS VSAFQRRFVV DVRRCEELEK TFTFLQEEVR RAGLVLPPPK GRLPAPPPRD LLRIQEETER LAQELRDVRG NQQALRAQLH QLQLHAAVLR QGHEPQLAAA HTDGASERTP LLQAPGGPHQ DLRVNFVAGA VEPHKAPALE RLLWRACRGF LIASFRELEQ PLEHPVTGEP ATWMTFLISY WGEQIGQKIR KITDCFHCHV FPFLQQEEAR LGALQQLQQQ SQELQEVLGE TERFLSQVLG RVLQLLPPGQ VQVHKMKAVY LALNQCSVST THKCLIAEAW CSVRDLPALQ EALRDSSMEE GVSAVAHRIP CRDMPPTLIR TNRFTASFQG IVDAYGVGRY QEVNPAPYTI IT (25-395 aa encoded by BC018133)
靶标信息
The T-cell immune regulator 1 (TCIRG1) is the a3 subunit of the vacuolar-type proton transporting ATPase (V-ATPase), a proton pump in late endosomes and lysosomes that functions in the luminal acidification of these organelles. Genetic defects in the gene encoding this protein a responsible for a severe form of autosomal recessive osteopetrosis, a condition that leads to increased bone density, decreased bone strength, and inflammation in bone tissues. TCIRG1 is also required for the normal secretion of insulin and the bacteria-killing function of macrophages.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ATPase, H+ transporting, 116kD; OC-116 kDa; Osteoclastic proton pump 116 kDa subunit; specific 116-kDa vacuolar proton pump subunit; T-cell immune regulator 1; T-cell immune response cDNA 7; T-cell immune response cDNA7 protein; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3; TIRC7; V-ATPase 116 kDa subunit a 3; V-ATPase 116-kDa; V-type proton ATPase 116 kDa subunit a; V-type proton ATPase 116 kDa subunit a 3; vacuolar proton translocating ATPase 116 kDa subunit A; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3
基因别名: a3; Atp6i; ATP6N1C; ATP6V0A3; OC-116kDa; OC116; OPTB1; Stv1; TCIRG1; TIRC7; Vph1
UniProt ID: (Human) Q13488
Entrez Gene ID: (Human) 10312
cellular defense response
vacuolar acidification
protein catabolic process in the vacuole
positive regulation of cell proliferation
insulin receptor signaling pathway
ATP synthesis coupled proton transport
ATP hydrolysis coupled proton transport
proton transport
macroautophagy
transferrin transport
ion transmembrane transport
vacuolar proton-transporting V-type ATPase complex assembly
phagosome acidification
