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Invitrogen
TCOF1 Polyclonal Antibody
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TCOF1 Antibody (PA5-120816) in WB
Western blot analysis of TCOF1 in extracts of various cell lines. Samples were incubated with TCOF1 Polyclonal antibody (Product # PA5-120816) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-120816
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 659-958 of human TCOF1 (NP_001008657.1).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
2.91 mg/mL
规格
291 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive test controls include: BT-474, 293T. The target is usually found in the following locations: Nucleus, nucleolus.
Immunogen sequence: VRVGTQAPRK AGTATSPAGS SPAVAGGTQR PAEDSSSSEE SDSEEEKTGL AVTVGQAKSV GKGLQVKAAS VPVKGSLGQG TAPVLPGKTG PTVTQVKAEK QEDSESSEEE SDSEEAAASP AQVKTSVKKT QAKANPAAAR APSAKGTISA PGKVVTAAAQ AKQRSPSKVK PPVRNPQNST VLARGPASVP SVGKAVATAA QAQTGPEEDS GSSEEESDSE EEAETLAQVK PSGKTHQIRA ALAPAKESPR KGAAPTPPGK TGPSAAQAGK QDDSGSSSEE SDSDGEAPAA VTSAQDQESS
靶标信息
Treacle is a serine/alanine-rich 1,411 amino acid nuclear phosphoprotein that interacts with upstream binding factor (UBF) and affects transcription of the ribosomal DNA gene. Treacle is also involved in early embryonic development, particularly in the craniofacial complex, and may play a role in nucleolarcytoplasmic transport. The Treacle protein contains three domains with unique N- and C-termini and a large central repeat domain. Mutations in TCOF1, the gene that encodes for Treacle, cause Treacher Collins-Franceschetti syndrome (TCS), a disorder characterized by defects in craniofacial development. Symptoms of TCS include conductive hearing loss, hypoplasia of the mandible and maxilla, downward sloping palpebral fissures and cleft palate.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
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