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Invitrogen
TCTN1 Polyclonal Antibody
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产品信息
PA5-24896
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide from the Central region of human TECT1 conjugated to KLH.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
Lot-specific
保存条件
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C
产品详细信息
PA5-24896 targets TECT1 in FACS, IHC, and WB applications and shows reactivity with Human samples.
The PA5-24896 immunogen is synthetic peptide from the Central region of human TECT1 conjugated to KLH.
靶标信息
TCTN1 is the founding member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. During embryonic development, TCTN1 is expressed in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13. 5 and E16. 5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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