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Invitrogen
TEM8 Polyclonal Antibody
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TEM8 Antibody (PA1-602) in WB
Western blot analysis was performed using membrane enriched extracts (30 µg) of Raji (Lane 1), U-87 MG (Lane 2), Hep G2 (Lane 3), Mouse Liver (Lane 4) and HeLa (Lane 5).The blots were probed with Anti-Anthrax Toxin Receptor Rabbit Polyclonal Antibody (Product # PA1-602, 1 in 1000 dilution) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.4µg/mL 1:2500 dilution). A~ 65kDa band of Anthrax Toxin Receptor was observed across the cell lines tested. A ~... View More
产品信息
PA1-602
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic Peptide: L(92) M K L T E D R E Q I R Q G L E(107) C
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 1mg/mL BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
PA1-602 detects Tem-8 from mouse samples.
PA1-602 has been successfully used in Western blot and immunohistochemical procedures. By Western blot, this antibody detects ~45 kDa, 60 kDa, 85 kDa proteins, representing Tem-8 from mouse tissue extracts.This antibody has also been used in immunohistochemical procedures (paraffin samples) using mouse tissues.
PA1-602 immunizing peptide corresponds to amino acid residues 92-107, within the extracellular domain, of human ATR/TEM8. This peptide (Cat. # PEP-253) is available for neutralization and control experiments.
靶标信息
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 2310008J16Rik; 2810405N18Rik; anthrax toxin receptor; Anthrax toxin receptor 1; FLJ10601; FLJ11298; FLJ21776; Tem-8; Tumor endothelial marker 8
基因别名: 2310008J16Rik; 2810405N18Rik; Antrx1; ANTXR1; ATR; GAPO; TEM8
UniProt ID: (Human) Q9H6X2, (Mouse) Q9CZ52
Entrez Gene ID: (Human) 84168, (Mouse) 69538
