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Abnova
TET1 Monoclonal Antibody (4F4)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00080312-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
4F4
抗原
TET1 (NP_085128.1, 2038 a.a. approximately 2136 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: RNHPTRLSLV FYQHKNLNKP QHGFELNKIK FEAKEAKNKK MKASEQKDQA ANEGPEQSSE VNELNQIPSH KALTLTHDNV VTVSPYALTH VAGPYNHWV
靶标信息
Dioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CXXC finger 6; CXXC zinc finger 6; CXXC-type zinc finger protein 6; LCX; leukemia-associated protein with a CXXC domain; RP11-119F7.1; ten-eleven translocation 1 gene protein; ten-eleven translocation-1; tet oncogene 1
基因别名: bA119F7.1; CXXC6; LCX
UniProt ID: (Human) Q8NFU7
Entrez Gene ID: (Human) 80312
RNA polymerase II core promoter proximal region sequence-specific DNA binding
DNA binding
iron ion binding
protein binding
zinc ion binding
methyl-CpG binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
methylcytosine dioxygenase activity
negative regulation of transcription from RNA polymerase II promoter
inner cell mass cell differentiation
chromatin remodeling
protein O-linked glycosylation
regulation of gene expression
stem cell population maintenance
negative regulation of cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
cellular response to reactive oxygen species
regulation of gene expression, epigenetic
hypomethylation of CpG island
positive regulation of transcription from RNA polymerase II promoter
negative regulation of stem cell population maintenance
positive regulation of stem cell population maintenance
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